NIPT is a kind of prenatal genetic testing that collects pregnant mom's peripheral blood to extract the fetal free DNA and uses a new generation of high-throughput sequencing technology that combines with biological information analysis to detect whether the fetus is at risk of chromosomal defects or diseases. Fetal free DNA in maternal peripheral blood is relatively high, so the extraction and analysis process is relatively simple and can be used for detection.
Compared with other traditional detection methods, NIPT is more non-invasive, safe, accurate, and fast. Its accuracy rate can be as high as 99%, effectively avoiding some unnecessary intervention operations and miscarriage caused by the diagnosis, and reducing the psychological pressure of pregnant women and their families. While it often takes one to two months to know the results, NIPT tests only need about 2 weeks to obtain accurate reports. This is because the blood hormone samples are used, which is faster and can effectively relieve the psychological pressure of pregnant women and their families.
NIPT tests can detect 21-trisomy, 18-trisomy, and 13-trisomy at the same time. It can also detect other chromosomal aneuploidies and chromosome deletions or duplications, especially the 8 major gene defects which are commonly seen in Asia. The common congenital diseases in Asians include thalassemia, Down syndrome and Huntington's disease etc.
In addition, the key to NIPT is non-invasive, that is, there is no harm to the fetus. It can reduce unnecessary biopsy and relieve prenatal pressure; reduce miscarriage caused by biopsy; reduce negative emotions such as pregnant women's anxiety, missed diagnosis and avoid medical disputes. Pregnant women can take the test before 9 weeks or more of their gestational week, and the test results are not affected by the age, race, or any pregnancy-related diseases of them.
Every parent hopes that the child is healthy, and everyone hopes that the child is not a patient with genetic diseases such as Down syndrome, trisomy 18 and 13 syndrome. However, the chromosomes of the fetus are all in the nucleus. In the past, there was no simple and direct detection method. Now it can be directly detected through NIPT.
It is recommended that the test is suitable for pregnant moms who are pregnant more than 10 weeks to obtain a more accurate result, because the fetal free DNA of the fetus under 10 weeks of pregnancy will be lessr, which will lead to increased inaccuracy of the test results.
Who is suitable for NIPT?
Pregnant women 35 years of age or older who belong to the high-risk group.
The family has chromosomal abnormalities.
Those who need to be exposed to radiation for a long time.
Smoking and drinking.
Pregnant women who want to know or exclude common fetal chromosomal diseases.
NIPT test is not suitable for :
Pregnant women who have undergone amniocentesis because of the risks associated with amniocentesis, such as incorrect fetal position, too little amniotic fluid, abnormal maternal blood coagulation, etc., which will lead to a relatively higher chance of miscarriage.